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In conclusion, hnf1a expression can reflect resistance to anticancer drug treatment, and its suppression improves anticancer drug sensitivity as a new therapeutic target. We demonstrated that triptolide directly bound to hnf1a, one of the transcription factors of shh, and inhibited hnf1a/shh expression, ensuing in attenuation of hedgehog signaling.
See Quinta Brunson Get Ready for the Tod's Fashion Show During Milan
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